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The prognostic factors of patients with colorectal liver metastases (CLM) have been traditionally searched among the factors related to the primary colorectal tumor or to CLM.
While many different scoring systems have been developed based on those traditional clinic-pathological factors, there has been the introduction of genetic biomarkers that added a theragnostic perspective.
More recently, other important factors, such as those related to the host immune system, have been proposed as new determinants of prognosis of CLM patients. We herein review the current prognosti....[more]
Prognostic Factors for Survival after Resection of Liver Metastases from Colorectal Cancer: A Single Institution Analysis of 655 Cas....
Sorin Alexandrescu, Andrei Diaconescu, Narcis Octavian Zarnescu, Zenaida Ionel, Cristian Zlate, Doina Hrehoret, Vladislav Brasoveanu, Razvan Grigorie, Florin Botea, Dana Tomescu, Gabriela Droc,Ruxandra Fota, Daniela Ungureanu, Adina Croitoru, Mirela Boros, Mugur Grasu, Radu Dumitru,Mihai Toma, Vlad Herlea, Mihnea Ionescu, Irinel Popescu
ORIGINAL PAPER, December 2017
Article DOI: 10.21614/sgo-22-4-291
Read article Background: Several clinical risk factors for patients undergoing liver resection for colorectal liver metastases were suggested. The purpose of the study was to evaluate the prognostic factors for survival after resection of liver metastases from colorectal cancer in a high volume center for both hepatobiliary and colorectal surgery.

Methods: We completed a retrospective analysis on 655 consecutive patients with liver resection for colorectal cancer metastasis operated in our centre between April 1996 and March 2016. Preoperative, intraoperative, pathologic, a....[more]
Targeted Confocal Laser Endomicroscopy (CLE) for the Assessment of Putative Cancer Stem Cell Markers in Colorectal cancer - A Pilot ....
Irina Florina Cherciu, Elena Tatiana Ivan, Daniela Elena Burtea, Mihaela Calita, Daniel Pirici, Claudiu Margaritescu, Adrian Săftoiu
ORIGINAL PAPER, December 2017
Article DOI: 10.21614/sgo-22-4-303
Read article Background: Colorectal cancer is one of the most common diagnosed malignancies in the world. Successful treatment is related not only to the resection of the main tumor mass but also to the destruction of colorectal cancer cells which are highly resistant to chemoradiotherapy, with unlimited self-renewal and tumor-initiating capacities.
CD44 is an important adhesion molecule and one of the proposed stem cell markers in colorectal cancer known to be involved in cell growth, differentiation and survival. Aim: We conducted a prospective study with the aim of evaluating the ....[more]
Impact of Postoperative Septic Complications on Recurrence of Colorectal Cancer
Miroslav Levy, Ludmila Lipska, Ladislav Sojka, Jaromir Simsa, Vladimir Visokai
ORIGINAL PAPER, December 2017
Article DOI: 10.21614/sgo-22-4-313
Read article Background: About one third of patients racically resected for colorectal cancer develop during follow-up recurrence. Materials and methods: There were 1951 patients operated for colorectal cancer in Surgical Department, Thomayer Hospital Prague, from 1997 to 2015.
Radical R0 operation underwent 68% of these patients. Postoperative complications occurred in 457 (34.6%) patients. Impact of postoperative complications on disease free interval was studied in a prospective study.

Results: We identified minor complications in 90 patients (6.8%), moderate complic....[more]
A Pilot Multicenter Study Evaluating the Expression of p53 and ki-67 in Gastric Tumors and Their Utility for Guiding Treatment Strat....
Il Hyun Baek, Kyoung Oh Kim, Jeong Won Kim, Kyeong Won Min
ORIGINAL PAPER, December 2017
Article DOI: 10.21614/sgo-22-4-318
Read article Background: p53 mutation is the most common genetic alteration in cancers and influences clinical progression. Ki-67 protein is a cellular marker for proliferation in cancer or premalignant lesion.
The aim of this study is to investigate whether p53 and Ki-67 measurements in gastric tumors would be helpful in determining treatment strategy.
Methods: Immunohistochemical staining using monoclonal antibodies to p53 and Ki-67 was performed on specimens from 29 gastric adenomas (GA) by endoscopic submucosal dissection (ESD) and 240 gastric cancers (GC) by ESD or g....[more]
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December 2017


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Print ISSN: 2559 - 723X

ISSN-L: 2559 - 723X

ISSN online: 2601 - 1700

Surgery, Gastroenterology and Oncology is indexed in Scopus, CrossRef (DOI: 10.21614/sgo)