Surgery, Gastroenterology and Oncology

Read article Successful liver transplantation requires proper mitigation of stress responses. Systemic effects caused by liver cirrhosis, invasive surgery, ischemia-reperfusion injury, rejection, and infection, all of which are relevant to liver transplantation, are mediated by inflammatory factors.
Recently, the detailed mechanisms of inflammation have been elucidated. Damageassociated molecular patterns (DAMPs) released from cells damaged by ischemia or injury, or pathogen-associated molecular patterns (PAMPs) released by pathogens, are recognized by internal cell receptors or cell surfac....[more]

Read article Domino Liver transplant (DLT) is a strategy to address organ shortage and expand the liver donor pool for liver transplantation. Despite offering some unique technical challenges, DLT appears to be a safe and reasonable option to be considered for selected patients who would otherwise not benefit from liver transplantation.
However, the benefit of expanding the donor pool must be balanced against the risk of disease transmission.In this review, we present where the DLT currently stands worldwide and our own experience with this procedure.

Read article Hepatocellular carcinoma (HCC) is the second cause of cancer–related deaths worldwide constitutes a major global health problem. Although our understanding of the molecular pathogenesis of hepatocellular HCC has improved, detected driver mutations are not yet sufficiently reliable therapeutic targets.
The modern management of HCC is conceived only within multidisciplinary schemes. Current systemic therapies are not curative and surgical treatments remain the only potential curative treatments for selected patients with early stage HCC.
The role of parenchyma sparing ....[more]

Read article The first wave of coronavirus disease 2019 (COVID-19) pandemic accounted for roughly 35,000 deaths in Italy and was mainly concentrated in the industrial north of the country.
Despite Italy returned to a partial lockdown during December, the number of people dying in the second wave has now surpassed the toll recorded in the first. This report aims to provide a snapshot of the impact of COVID-19 on liver transplantation activity in our Institution, with special regard to the measures put in place to guarantee through the two waves of the pandemic.
LT activity continued in....[more]