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Hepatocellular carcinoma (HCC) is the most common primary liver malignancy worldwide, and a leading cause of global cancer-related mortality. However, a multitude of risk factors results in heterogeneous tumor biology that can demonstrate widely different clinical behaviors. Chronic inflammation represents the predominant etiology of HCC, and up to 80-90% of cases occur in the setting of cirrhosis. The underlying liver disease observed in most patients adds an additional level of clinical complexity not present in most other cancers. Careful consideration of the tumor biology, liver ....[more]
The Pathogenesis of Gastric Carcinoma
Elroy Patrick Weledji
REVIEW, Apr 2017
Article DOI: 10.21614/sgo-23-2-106
Read article Gastric cancer is one of the leading causes of cancer mortality in the world. Gastric adenocarcinomas account for more than 95% of gastric tumours, and these epithelial tumours result from the accumulation of multiple genetic defects which leads to uncontrolled growth. The most plausible pathway for gastric carcinoma indicates that the underlying mechanisms may be different for the diffuse and intestinal types of tumour.
The distinct subtypes - proximal, diffuse and distal gastric cancer that are different from a histological and epidemiological standpoint, can also distinguish....[more]
Red-flag Techniques for the Assessment of Pre-Neoplastic Gastric Lesions: Autofluorescence Imaging versus Virtual Chromoendoscopy
Maria Monalisa Filip, Sevastiţa Iordache, Elena Daniela Burtea, Mihaela Căliţa, Adrian Săftoiu
Article DOI: 10.21614/sgo-23-2-115
Read article Background Aim: The endoscopic diagnosis of preneoplastic lesions and early gastric cancer is based on subtle morphological changes, which are difficult to recognize during routine examinations. The study was performed in order to establish the role of autofluorescence imaging (AFI) and magnifying endoscopy with narrow band imaging (ME-NBI) for the diagnosis of premalignant gastric lesions.

Methods: The study included patients with dyspeptic symptoms and or known risk factors for gastric cancer. Imaging consisted of white light endoscopy (WLE), followed by AFI....[more]
The Combination of Serum Cystatin C, Urinary Kidney Injury Molecule-1 and MELD plus Score Predicts Early Acute Kidney Injury after L....
Marian-Irinel Tudoroiu, Georgiana Constantin, Liliana Pâslaru, Speranţa Iacob,Cristian Gheorghe, Irinel Popescu, Dana Tomescu, Liliana Simona Gheorghe
Article DOI: 10.21614/sgo-23-2-121
Read article Introduction: Acute kidney injury (AKI) following liver transplantation (LT) is a frequent complication and is associated with increased morbidity and mortality.

Aim: To investigate whether the levels of urinary KIM-1 and serum Cystatin C are able to predict early occurrence (within the first 48 hours) of the post-LT renal dysfunction. Methods: The study was conducted on 25 recipients transplanted in the Fundeni Clinical Institute between May 2016 and February 2017. Serum Cystatin C, urinary KIM-1 and serum creatinine were analysed before LT, as well as....[more]
Strategies and Techniques for the Treatment of Concomitant Gallbladder and Common Bile Duct Stones: An Economic Dilemma Only?
Antonio Zanghi, Andrea Cavallaro, Sergio Castorina, Maria Di Vita, Laura Fisichella, Francesco Cardi, Fabio Melandro, Alessia Giaquinta, Alessandro Cappellani
Article DOI: 10.21614/sgo-23-2-127
Read article Background: Single stage laparoendoscopic rendez-vous (LERV), single-stage laparoscopic common bile duct exploration - cholecystectomy (LCBDE), and two-stage endolaparoscopic (LC-ERCP) management of cholecystocholedocholithiasis can be performed with similar short and long-term outcomes. This multicentric study retrospectively examined the outcome and hospital costs of one-stage vs. sequential two-stage strategies of treatment.

Methods: From January 2013 to December 2016, all the patients affected by cholecystocholedocholithiasis and treated at 2 different med....[more]
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Apr 2018


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Print ISSN: 2559 - 723X

ISSN-L: 2559 - 723X

ISSN online: 2601 - 1700

Surgery, Gastroenterology and Oncology is indexed in Scopus, CrossRef (DOI: 10.21614/sgo)

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