Surgery, Gastroenterology and Oncology

Background: The efficacy of gelatin-thrombin matrix sealants (Floseal®) for hemostasis has been well described in the field of cardiovascular surgery, but data supporting its safety and efficacy in liver surgery remains lacking.

Methods: The surgical outcomes of 83 consecutive patients in whom Floseal® was applied during hepatectomy were reviewed. The severity of bleeding before and after the application of Floseal® was graded according to the Validated Intraoperative Bleeding (VIBe) Scale.

Results: Flo....[more]

Background: HCV chronic infection is a leading cause of end-stage liver disease and liver transplantation. The aim of our study was to assess the benefits of novel anti-HCV therapeutic approaches in obtaining viral clearance, in reducing liver inflammation, in regression of fibrosis, and improvement of liver-related morbidity and mortality.

Material and methods: We performed an observational, prospective, non-interventional study in 260 patients with HCV chronic infection and advanced liver fibrosis (F3 and Child class A liver cirrhosis), ....[more]

Background: The most common types of true epithelial exocrine pancreatic cystic neoplasms are serous cystic neoplasms (SCNs), mucinous cystic neoplasms (MCNs), intra-ductal papillary mucinous neoplasms (IPMNs), and solid pseudo-papillary neoplasms (SPPNs). Both open and laparoscopic pancreatic surgeries are major procedures with significant morbidity and mortality rates. This study aimed to determine the outcomes of laparoscopic pancreatic surgery in managing true exocrine epithelial pancreatic cystic neoplasms in terms of postoperative pancreatic fistula and recu....[more]

Background: Gastrointestinal stromal tumours (GISTs) are uncommon sarcomas. Surgery and target therapy are the primary modalities in treating GIST. KIT expression is the cornerstone in diagnosis of GIST, yet its expression is absent in a small percent of GISTs. The precise behaviour and treatment effects, particularly target therapy, and the prognosis of these cases are unclear; hence this study was designed to investigate them.

Methods: In the current retrospective cohort research, all patients with GIST who presented and w....[more]