Surgery, Gastroenterology and Oncology

Read article Nonalcoholic fatty liver disease (NAFLD) represents the accumulation of lipids in the hepatocytes, lipids represented by triglycerides (most frequently), cholesterol, phospholipids, and sphingolipids.
NAFLD is rapidly becoming one of the most important causes of chronic liver disease, liver cirrhosis and liver transplantation in developed countries. It can present as simple steatosis, which is usually a benign condition, to steatohepatitis, which may lead do advanced fibrosis and cirrhosis. Although there are many risk factors for the development of fatty liver disease, a centr....[more]

Read article Objectives: To study the function of the gastric mucosa and acid secretion after bariatric surgery, GastroPanel (GP), serum biomarker test was performed in 29 laparoscopic sleeve gastrectomy (LSG) and 28 laparoscopic Roux-en-Y gastric bypass (LRYGB) patients before and after surgery.

Methods: Pepsinogen I (PGI), II (PGII), basal fasting gastrin-17 (G17b), stimulated gastrin-17 (G17s) and Helicobacter pylori antibody (HPAB) levels in serum were assayed preoperatively, postoperatively on days 1 and 3, and after 1, 3 and 12 months.

Results: The serum....[more]

Read article Background: Biliary strictures (BSs) often represent a diagnostic challenge when evaluated with conventional endoscopic techniques. Many recent studies have focused on the specificity, sensitivity and accuracy of digital single-operator cholangioscopy (DSOC) in cases of BSs. However, DSOC is not a standardized procedure and the institutional experience with DSOC when used in different settings can provide important information.

Methods: This is prospective study of consecutive patients undergoing DSOC from March 2016 until March 2018. The aims of the study wer....[more]

Read article Introduction: Prognosis of metastatic colorectal cancer (mCRC) patients nowadays is an important subject in the field of oncology. R0-resection of colon with primary tumor and liver metastasis remains the only treatment which significantly improves survival rate. However, recent experimental data shows that surgical trauma can indirectly stimulate tumor growth due to mitochondrial dysfunction and unregulated superoxide radical (O2-.) generation.

Aim: To study the clinical significance of 8-hydroxy-deoxyguanosine (8-OHdGu) marker, to assess the oncological effec....[more]