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While relatively infrequent, cholangiocarcinomas (CCAs) are liver cancers whose incidence is increasing worldwide.Unfortunately, the progress in medical, surgical and radiation oncology treatment of CCAhas made little strides in the survival of patients in most regions of the world over the past several decades.
As a result, CCA therapy remains a major challenge in medicine. There are multiple reasons for limited advances in CCA care. These include:
(1) the lack of standardized surgical approaches,
(2) the relatively difficulty of conducting clinical trials due to t....[more]
Basic Surgical Pathology of Perihilar Cholangiocarcinoma: Bridging Knowledge for Surgical Practice
Tomoki Ebata, Takashi Mizuno, Yukihiro Yokoyama, Tsuyoshi Igami, Junpei Yamaguchi, Shunsuke Onoe, Nobuyuki Watanabe, Masato Nagino
REVIEW, Aug 2018
Article DOI: 10.21614/sgo-23-4-219
Read article Perihilar cholangiocarcinoma (PCC) is a devastating disease with poor prognosis. Surgical resection remains a first-line therapy in patients with PCC, and the primary goal is to gain a tumor-free surgical margin.

However, surgical margins are sometimes involved after curative intent surgery even now, which is plausibly explained by the fact that there is a potential gap between the extent of radiologic tumor staging and that of histologic cancer invasion.
It is known that cancer cells of cholangiocarcinoma invade the surrounding area beyond the gross tumor border. The....[more]
Liver Transplantation for Perihilar Cholangiocarcinoma in the Era of Transplant Oncology: Urgent Need for a Common Definition of Res....
Keita Shimata, Hidekazu Yamamoto, Yasuhiko Sugawara, Taizo Hibi
REVIEW, Aug 2018
Article DOI: 10.21614/sgo-23-4-225
Read article The indications for liver transplantation in hepatobiliary malignancies have been carefully expanded, giving rise to a new era of Transplant Oncology, the fusion of transplantation medicine and oncology.
Curative resection is the only curative therapy for perihilar cholangiocarcinoma. Liver transplantation may achieve a complete resection with adequate negative margins in patients with locally advanced, unresectable disease due to bilateral invasion of second-order biliary radicals, portal vein and or hepatic artery involvement, or insufficient hepatic reserve.
An aggress....[more]
Surgical Strategies for the Management of Perihilar Cholangiocarcinoma
Mohamed Abdel Wahab, Ahmed Shehta, Mahmoud Ali
REVIEW, Aug 2018
Article DOI: 10.21614/sgo-23-4-230
Read article Cholangiocarcinoma is a fatal cancer arising from the biliary endothelium. Perihilar cholangiocarcinoma (pCCA) is the most common variant of cholangiocarcinoma, with increasing incidence worldwide.
Most pCCA patients present with unresectable disease at the time of diagnosis, and many patients are found to be unresectable after surgical exploration. pCCA carries a poor prognosis as more than 65% of the patients are presented with non-resectable disease at the time of diagnosis, and about 10% to 45% of patients are found to be unresectable after surgical exploration.
Preoperative Management of Patients Undergoing Liver Resection for Perihilar Cholangiocarcinoma
Mariano Cesare Giglio, Federico Tomassini, Sara Maritato, Giammauro Berardi, Nikdokht Rashidian, Roberto Montalti, Roberto Ivan Troisi
REVIEW, Aug 2018
Article DOI: 10.21614/sgo-23-4-241
Read article Surgical resection with negative margins is the standard treatment for perihilar cholangiocarcinoma whenever possible. Patient's frequent low performance status at presentation and need of extended resections require optimization of the patient's condition in the preoperative setting. Biliary drainage is mandatory in case of cholangitis, jaundice-related liver insufficiency, malnutrition or renal failure.

Drainage is also necessary in case of portal vein embolization (PVE), in order to improve regeneration of the future liver remnant (FLR). Unilateral drainage of the FLR sh....[more]
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Print ISSN: 2559 - 723X

ISSN-L: 2559 - 723X

ISSN online: 2601 - 1700

Surgery, Gastroenterology and Oncology is indexed in Scopus, CrossRef (DOI: 10.21614/sgo)

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