Surgery, Gastroenterology and Oncology

Read article Background Aims: The effect of splenectomy on the liver regeneration of a partial graft after living donor liver transplantation (LDLT) is controversial. In recent years, some studies have shown that platelets have strong effects on promoting liver regeneration, but not with a smallfor- size liver graft. This study aimed to validate the effects of splenectomy on liver regeneration rate after LDLT with extended left lobe graft with the middle hepatic vein.

Methodology: Of 312 LDLT to date, 32 adult patients at Nagasaki University Hospital (Nagasaki, Japan) transp....[more]

Read article Background Aims: Nutlin3a is known to have effects of stabilization of p53 and degradation of Poly(ADP-ribose) polymerase 1 (PARP1) in cell-specific manner. It was demonstrated that nutrlin3a decrease tissue damage caused by ischemia reperfusion (I R) in transplant settings such as lung. We aimed to evaluate if the reagent would still alleviate hepatic I R injury.

Methodology: First, to evaluate an efficacy of nutlin3a in normal liver, we administered it to male C57Bl 6 mice intraperitoneally at doses of 0 (vehicle only), 5, and 20 mg kg of body-weight. The an....[more]

Read article Background: The iatrogenic injury of the bile ducts is a serious accident of laparoscopic cholecystectomy. Its management is multidisciplinary. The aim of our work was to elucidate the factors influencing the long-term results after biliary repair.

Methods: A retrospective, analytical and descriptive study was carried out on a series of 44 cases of biliary injuries repaired over a period of 14 years.

Results: The injury was discovered intraoperatively in 18 cases, in early postoperative period in 20 cases and in late postoperative period in 6 case....[more]

Read article Objective: To evaluate the outcomes, safety and effectiveness of laparoscopic total gastrectomy with D2 lymph node dissection with left-site surgeon and resection - closure of the duodenal stump in final phase after making esophageal anastomosis in gastric cancer treatment.

Method: Prospective, descriptive study on patients undergoing laparoscopic total gastrectomy and D2 lymphadenectomy with left-site surgeon and resection - closure of the duodenal stump in final phase after making esophageal anastomosis in gastric cancer treatment from 06 2016 â?" 03 2020. <....[more]