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Identification of biomarkers that correlate with prognosis is crucial in hepatocellular carcinoma (HCC) because of the high recurrence rates seen after surgical treatments. Serum levels of fetoprotein (AFP) are widely used clinically, but the prognostic value of AFP remains unclear.
AFP levels are influenced not only by the presence of HCC but also by the severity of the underlying liver disease. Furthermore, AFP could be normal in up to 30% of HCC patients. Thus, additional biomarkers are needed. Insulin-like growth factors 1 (IGF-1) is a growth factor with dose-dependent prol....[more]
Non-Alcoholic Fatty Liver Disease: What We Need to Know
Luminita Leurzeanu, Laura Carstocea
REVIEW, Apr 2019
Article DOI: 10.21614/sgo-24-2-80
Read article Nonalcoholic fatty liver disease (NAFLD) represents the accumulation of lipids in the hepatocytes, lipids represented by triglycerides (most frequently), cholesterol, phospholipids, and sphingolipids.
NAFLD is rapidly becoming one of the most important causes of chronic liver disease, liver cirrhosis and liver transplantation in developed countries. It can present as simple steatosis, which is usually a benign condition, to steatohepatitis, which may lead do advanced fibrosis and cirrhosis. Although there are many risk factors for the development of fatty liver disease, a centr....[more]
Serum Gastric Biomarker Levels After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Operations: A Prospective Study with 1-year Fol....
Jaanus Suumann, Toomas Sillakivi, Zivile Riispere, Kari Syrjänen, Pentti Sipponen, Ülle Kirsimägi, Ants Peetsalu
ORIGINAL PAPER, Apr 2019
Article DOI: 10.21614/sgo-24-2-86
Read article Objectives: To study the function of the gastric mucosa and acid secretion after bariatric surgery, GastroPanel (GP), serum biomarker test was performed in 29 laparoscopic sleeve gastrectomy (LSG) and 28 laparoscopic Roux-en-Y gastric bypass (LRYGB) patients before and after surgery.

Methods: Pepsinogen I (PGI), II (PGII), basal fasting gastrin-17 (G17b), stimulated gastrin-17 (G17s) and Helicobacter pylori antibody (HPAB) levels in serum were assayed preoperatively, postoperatively on days 1 and 3, and after 1, 3 and 12 months.

Results: The serum....[more]
Digital Single-Operator Cholangioscopy in the Management of Biliary Strictures - Our Initial Institutional Experience
Petko Karagyozov, Irina Boeva, Ivan Tishkov, Violeta Mitova, Kiril Draganov
ORIGINAL PAPER, Apr 2019
Article DOI: 10.21614/sgo-24-2-95
Read article Background: Biliary strictures (BSs) often represent a diagnostic challenge when evaluated with conventional endoscopic techniques. Many recent studies have focused on the specificity, sensitivity and accuracy of digital single-operator cholangioscopy (DSOC) in cases of BSs. However, DSOC is not a standardized procedure and the institutional experience with DSOC when used in different settings can provide important information.

Methods: This is prospective study of consecutive patients undergoing DSOC from March 2016 until March 2018. The aims of the study wer....[more]
DNA Oxidation in Patients with Metastastic Colorectal Cancer: Clinical Significance of 8-Hydroxy-Deoxyguanosine as an Independent Pr....
Anatoliy Burlaka, Anastasia Vovk, Anton Burlaka, Olena Kolesnik
ORIGINAL PAPER, Apr 2019
Article DOI: 10.21614/sgo-24-2-100
Read article Introduction: Prognosis of metastatic colorectal cancer (mCRC) patients nowadays is an important subject in the field of oncology. R0-resection of colon with primary tumor and liver metastasis remains the only treatment which significantly improves survival rate. However, recent experimental data shows that surgical trauma can indirectly stimulate tumor growth due to mitochondrial dysfunction and unregulated superoxide radical (O2-.) generation.

Aim: To study the clinical significance of 8-hydroxy-deoxyguanosine (8-OHdGu) marker, to assess the oncological effec....[more]
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Print ISSN: 2559 - 723X

ISSN-L: 2559 - 723X

ISSN online: 2601 - 1700

Surgery, Gastroenterology and Oncology is indexed in Scopus, CrossRef (DOI: 10.21614/sgo)



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