Surgery, Gastroenterology and Oncology

Purpose: Patients with Cowden syndrome (CS) have an increased lifetime risk of developing cancers, particularly breast, uterus, thyroid, colon and renal cell cancer. CS is associated with a germline mutation of PTEN, a gene that plays an important role in carcinogenesis. This review hypothesized that inactivation of PTEN could have dramatic consequences on response of treatments in patients with Cowden Syndrome.

Methods: This systematic review has been reported in line with PRISMA and AMSTAR, we investigated to deficit of PTEN and the resp....[more]

Background: Alcohol consumption is increasing worldwide, as being the most popular drug used for recreational purposes. Excessive consumption leads to irreversible liver damage, and since 2015 alcoholic cirrhosis has become the main indication of liver transplantation (LT).

Methods: Our aim was to create the epidemiological profile, of the cirrhotic patient who consumes alcohol and is considered a candidate for LT. Evaluation of alcohol consumption by applying three screening questionnaires: CAGE, AUDIT-C and FAST. Survival ....[more]

Objective: Patients with acute diverticulitis (AD) have an increased risk of underlying colorectal cancer (CRC), however those with uncomplicated AD may have the same underlying population risk. Despite evidence suggesting these patients may not require further endoscopy, published guidelines still recommended Colonoscopy as standard post-diverticulitis management. A practical approach to the definition of bowel wall thickening may improve negative predictability, a potential impediment to omitting colonoscopic followup.

Material and Methods: A 2-year (July 2....[more]

Introduction: The functional laparoscopic gastric bypass with fundectomy and gastric remnant exploration (LRYGBfse) has been described in attempt to overcome the intrinsic limitations of the LRYGB with promising results. However, the detailed learning curve related to this innovative procedure has not been assessed.

Materials and Methods: Retrospective multicenter study from December 2010 to January 2015. Data were prospectively collected from one surgeon experienced in laparoscopic surgery. The cumulative summation methodol....[more]