Surgery, Gastroenterology and Oncology

Read article Standard cytotoxic chemotherapy is effective for certain type of cancer; however, as far as many other types are concerned, the available treatments only offer a limited survival benefit. Lung cancer represents one of these types of cancer. The development of specific therapies is the greatest promise for the successful treatment of this disease; nevertheless, an oriented approach depends on the understanding of the tumor cells genome. The exon sequencing of a large number of lung cancer samples has provided an initial insight of the somatic mutation profile of these tumors. These st....[more]

Read article Uterine sarcomas are rare but very aggressive uterine malignancies originating from mesenchymal elements of the uterine wall. They are classified by the "Gynecologic Oncology Group" in nonepithelial neoplasms and mixed epithelial-nonepithelial tumors, each category presenting different features and rognostic factors. In this review we present the main characteristics and the current therapeutic options for each type of primary uterine sarcoma and for their recurrences.

Read article Ischemic stroke is a major cause of death and disability worldwide. Intravenous administration of recombinant tissue plasminogen activator (rtPA) is the only approved pharmacological therapy for patients with acute ischemic stroke. Treatment with intravenous rtPA is associated with increased rates of intracranial hemorrhage. This review discusses recent findings about the changes of the components of neurovascular unit and the alteration of blood-brain barrier during stroke. The analysis provide information in order to identify factors with predictive value for hemorrhagic transforma....[more]

Read article Objectives. The paper aims are: to present and illustrate the MRI aspects of the normal and pathological bone marrow involving the spine, focusing on MR techniques and interpretation in a precise clinico-biological context of each patient. Material and methods. The cases included in this study were explored using a 1.5 MRI system in T1-weighted, T2 FSE, STIR, FSE T2 Fat Sat sequences, in sagittal and or coronal plane. Sections made in the axial plane in T2 wi, were centered at the level of the lesion(s). In case of primitive or secondary tumoral lesions we have performed T1-weighte....[more]

Read article Renal transplantation represents the main method of renal substitution in uraemic patients. The decreased supply of organs, in the conditions of a high organ demand, has determined an increasing number of patients on the waitinglist, and also of the cardiovascular events. The purpose of ourstudyis to establish the frequency and the gravity of the cardiovascular events, as well as the associated risk factors existing in uraemic patients that were included or not in renal substitution treatment programs, prior to inclusion on the transplant waitinglist, in the Nephrology Center of the....[more]

Read article Introduction and Purpose. To evaluate the role of MRI in the study of the pulmonary artery (PA) and the system of aorto-pulmonary collateral vessels, in patients with tetralogy of Fallot or different forms of variants. Methods. Retrospective study covering the period 1 January 2001 - June 1, 2013. We have studied the clinical and imaging data of 32 consecutive patients (diagnosed with tetralogy of Fallot or different forms of variant pulmonary stenosis), sent for MRI examination. The goal of the MRI examination was to depict the anatomy of the pulmonary vascular system and to imag....[more]

Read article Background. The diabetic foot is a complex pathologic entity that includes modifications occurred at the foot level, which can be found either at the layer of nerve, skin, bone or muscle tissue, either on blood vessels. A special issue is that of tardiness in coming to the doctor in such patients that have severe lesions, for the most part requiring the performance of a minor or major amputation, long periods of treatment and permanent social assistance. Data from the medical literature are showing that early and adequate care given to diabetic foot lesions may prevent amputation o....[more]

Read article In cases with advanced cervical cases, with large lymph node metastases or solitary peritoneal masses the patient is candidate rather for debulking surgery than systemic treatments. Several studies have proven that radiotherapy is inefficient for tumoral masses larger than 2 cm. In this case report we present a 55 years old patient with advanced cervical cancer, large lymph node metastasis and a solitary peritoneal mass. A radical hysterectomy with bilateral adnexectomy,lymph node dissection and mesosigmoid mass resection were performed. The patient was addressed to adjuvant chemot....[more]

Read article Vaginal cancer represents a rare malignancy accounting for 2% of all gynecologic malignant tumors. Due to its rarety, there are no prospective trials to guide the treatment. The most commonly used treatment option is radiotherapy. We present the case of a 75 years old female who was addressed to our service for vaginal bleeding. The local exam showed the presence of a large tumor on the posterior vaginal wall and the biopsies revealed squamous cell carcinoma. The patient was refferred to the radiotherapy service but after 5 sequences of external beam therapy associated with chemoth....[more]