Surgery, Gastroenterology and Oncology

Read article Background: An ideal liver allocation system should reduce waitlist mortality and also improve post-transplant survival.

Aim: To identify a new scoring system that predicts recipient survival at 3 months following liver transplantation (LT) in the Romanian program.

Methods: We included into analysis 242 adult patients (183 patients within the training set and 59 in the validation cohort) with liver cirrhosis consecutively transplanted between January 2012 and June 2014.

Results: Post-transplant overall survival was 84.2% at 3 months....[more]

Read article Recent works focus on the role microRNAs (miRNAs) play in regulation of cardiovascular pathology. One of the miRNAs highly expressed in cardiovascular system is miR-21. The aim of this study was to investigate the relationship between the expression level of miR-21 in cardiac disease and correlate with TGF-b1, one of its targets.

Methods: Plasma samples from patients with CVD (cardiovascular diseases) established according to clinical and paraclinical exams were subjected to total RNAs isolation. miR-21 expression levels in patients with CVD and in healthy control subje....[more]

Read article Objectives: To evaluate the morbidity of ureteral access sheath (UAS) use during retrograde flexible ureteroscopy, and after a minimum follow-up period of 18 months.

Methodology: We prospectively evaluated 237 patients treated by retrograde flexible ureteroscopic approach for single pyelocaliceal stones: 126 in which a 10 12F UAS was used were compared with 111 in which the procedure was performed without it. Patients were followed for at least 18 months. 15% of the first group and 12.6% of the second one were JJ stented preoperatively. UAS related ureteral wall....[more]

Read article Pancreatic cancer is associated with high rates of mortality especially due to advanced stages of diagnosis. Adjuvant chemotherapy role is thus essential in the attempt to downstage the tumoral grade. In cases of locally advanced tumors, this step could be followed by curative surgical resection.
Characterization of predictor biomarkers for adjuvant chemotherapy has drawn increasing interest in molecular biology research of pancreatic cancer. Personalized treatment is one of the solutions proposed for advancing towards a better outcome. In this paper we discuss available predicto....[more]

Read article CA 125 is one of the most popular tumor markers usually synthetized by normal and malignant cells of different origins.
Increased levels can be found in both benign and malignant conditions in fluids with different origins such as pleural effusion, ascites, ovarian cysts fluids, amniotic fluid and even pancreatic cyst fluids. This is a literature review of the largest studies regarding various conditions in which increased levels of CA 125 can be found and their clinical significance.

Keywords: CA 125, amniotic fluid, cyst fluid, ascites, pleural effusion

Read article Background: Isolated pancreatic metastases of other neoplasms are an uncommon pathology, particularly with a colo-rectal cancer origin. Surgery represents the single hope for a long-term survival in these patients, but most of the previously reported patients in the literature underwent standard pancreatic resections.
A central pancreatectomy is a non-standardized pancreatic resection, which was exceptionally reported for a malignant pathology.

Case presentation: A 30-years old male, with previously left hemicolectomy for a sigmoid colon adenocarcinoma and l....[more]

Read article Introduction: Combined vasculo-biliary injuries, including biliary duct, hepatic artery and portal vein, arevery rare, but severe complicationsafter cholecystectomy due to their high morbidity and mortality.

Case presentation: We present a D4dpv (according to Hanover-classification of biliary injuries) biliary tract injury in a 41-years-old lady who underwent an elective laparoscopic cholecystectomy with a conversion for a massive bleeding from portal vein. Total transection of the common hepatic duct, sutured portal vein, narrowed up to 25 % at the near trifurc....[more]

Read article Prostate cancer (PC) is one of the most prevalent malignant tumour in men, especially in elderly patients. The aim of this paper is to present and illustrate the utility of multiparametric (MP) MRI in the diagnostic of PC. A 66 years old patient with clincal suspicion of PC was explored by MP MRI.
The MR examination included T2-wi, dynamic contrast-enhanced (DCE) MRI and diffusion-weighted imaging (DWI) acquisitions.
The final MR diagnosis was prostate tumor with the TNM-stage T4 N1 Mx. Radical prostatectomy revealed a Gleason score 7 (4+3) adenocarcinoma with extraprostatic ....[more]

Read article Background: Neonatal Graves-Basedow disease is a rare and transient complication due to mother's Basedow disease, occurring extremely rare due to Hashimoto thyroiditis or as a persistent hyperthyroidism due to activating mutations of the Thyroid-Stimulating Hormone (TSH) receptor. It may cause goiter and hyperthyroidism in the neonate, prematurity or fetal death, in some cases needing therapy and pre-conception counseling.

Case presentation: We report the case of a premature newborn from a mother who underwent total thyroidectomy for Basedow disease 7 years befo....[more]

Read article Lymphomatous involvement of pericardium is relatively commonly seen in patients diagnosed with Hodking and non-Hodgking disease, presenting large mediastinal mass.
Pericardial and cardiac involvement may be a late manifestation of lymphoma. Pericardial nodular thickening or effusion, a tumoral mass extending into the superior pulmonary veins are signs of secondary tumoral pericardial involvement. But pericardial effusion is not a specific and reliable sign of tumoral pericardium, because in patient with lymphoma can be seen postradiotherapy or in case of infection.
Familiarit....[more]

Read article Synchronous ovarian and uterine cervix malignancies are extremely rare gynecologic neoplasia. In the meantime the presence of hepatic metastases originating from cervical cancer is another rare situation, the liver being more often a common site of metastases for ovarian malignancies.
We present the case of a 63-year-old patient who was diagnosed with a moderately differentiated squamous cell cervical tumor with urinary bladder invasion associated with an ovarian tumorand liver metastases. An anterior exenteration and atypical liver resection were performed; the histopathological....[more]