Surgery, Gastroenterology and Oncology

Read article The discovery of non-coding RNAs (ncRNAs) dramatically changed the understanding of cancer mechanisms in the last decade. The ncRNAs interplay with protein-coding genes and their abnormalities represents one the most unexpected and important discoveries in the cancer field.
Cancer initiation, progression and dissemination causally involve the effects of small regulatory ncRNAs named microRNAs, mainly due to deregulation of expression of cancer protein coding genes. miRNAs can act as oncogenes (activating malignant potential) or tumor suppressors (inhibiting malignant potential) d....[more]

Read article Back in 1996, as a newly appointed Associate Professor of Surgery, I decided to start a scientific journal of Fundeni Hospital, the place where I worked, inspired by the long and uninterrupted tradition in research at this largest and arguably the best medical health care institution in Romania.
The name of the Journal was Annals of Fundeni Hospital. In this difficult endeavor, I took as Associate Editor an enthusiastic and very promising young gastroenterologist, still vascillating between clinical work and basic research. His name was George Calin. The passion for geneti....[more]

Read article The risk of excessive bleeding and thrombotic complications coexist in cirrhotic patients due to synthetic reduction in both pro and anticoagulants. However, investigators suggest the prevalence and consequences of thrombotic complications are underestimated. There is convincing evidence that thrombosis causes worsening portal hypertension, hepatic fibrosis and increases patient mortality.
New evidence is emerging about the benefits of treating and preventing thrombotic complications in patients with liver disease. In the absence of welldesigned trials, clinical experience has be....[more]

Read article The 1.1B4 cell line is a novel human hybrid formed by electrofusion of primary culture of human pancreatic islets with PANC-1. Our analysis of functional parameters of this cell line (insulin expression and secretion, glucose responsiveness, staining with human specific antibodies) confirmed the human identity and the inherited properties of functional beta cells.

Irradiation with HDGP (High Density Green Photons) of two beta pancreatic cells lines (1.1B4 and INS-1E) and of human pancreatic islets induced modifications in insulin, pro-insulin and glucagon expression and secre....[more]

Read article A different type of experimental set-up is developed, in which cellular systems irradiated with ultraviolet (UV) light are protected through a simultaneous irradiation with high density green photons. The noxious UV-effects and their protection by green light (GL) are investigated on Saccharomyces cerevisiae (Sc) - cells, cultivated and measured under rigorous conditions.
A series of physical determinations, atomic force microscopy, impedance spectroscopy and circular dichroism, revealed that the alterations induced by UV in the cellular culture were clearly reduced through the s....[more]

Read article Background: Rosacea is a chronic inflammatory dermatosis, frequently associated to various gastrointestinal disorders. Recent studies suggest that intestinal alkaline phosphatase, an enzyme that guards intestinal homeostasis might be involved in the pathogenesis of rosacea.

Objective: The objective of this study is to investigate serum intestinal alkaline phosphatase - (IAP) enzymatic activity levels in rosacea patients and correlate them with different clinical forms.

Methods: Twenty six rosacea patients and twenty three age - and sex-matched hea....[more]

Read article Retrograde jejunogastric intussusception is a well-recognized, rare, but potentially life threatening long-term complication of gastrojejunostomy. Diagnosis of this condition is difficult in most cases.

We report on such a patient who presented with overt upper gastrointestinal bleeding. The complication developed thirty years after the primary surgery without history of acute upper abdominal pain in spite of a long segment of gangrenous jejunum inside the stomach. Resection and refashioning of the gastrojujenostomy was performed.

Read article Phyllodes tumors (PTs) are uncommon neoplasms of the breast, constituting 0.3 to 0.9% of all breast tumors in females comprised of both stromal and epithelial elements. The term cystosarcoma phyllode was coined by Johannes Muller, a misleading term as tumors are rarely cystic and the majority follow a benign clinical course.

The term giant phyllodes is used when the tumor size exceeds 10 cm in diameter. WHO (World Health Organization) classification has identified three categories of phyllodes tumors of the breast (PT): benign, borderline and malignant. The mainstay of treatm....[more]

Read article
Oral presentations:

• LIVER TRANSPLANTATION (LT) USING DCD DONORS WITH 20 MINUTES NO TOUCH PERIOD: PRELIMINARY ITALIAN EXPERIENCE AT NIGUARDA CA GRANDA HOSPITAL
• Renal perfusion, function and oxygenation in the early postoperative period after liver transplantation
• AN INCIDENTAL FINING DURING PERIOPERATIVE USE OF TRANSOESOPHAGEAL ECOGRAPHY FOR ORTHOTOPIC LIVER TRANSPLANT....[more]