Surgery, Gastroenterology and Oncology

Read article Ischaemic mitral regurgitation is a relatively common finding in patients with acute or chronic coronary disease, as a consequence of left ventricular remodelling. Irrespective of its severity, ischaemic mitral regurgitation is an independent predictor of cardiovascular events and death.
In this review, we discuss the current recommendations for a comprehensive evaluation of mitral regurgitation mechanism and severity, using standard and novel imaging techniques, and also the most recent results from randomized trials regarding complex interventional and surgical treatment choic....[more]

Read article Currently, the treatment of liver metastases of colorectal cancer (CRC) requires a multidisciplinary approach and should be individualized for each patient. Liver resection provides 5 years survival rates ranging between 30 and 58% in patients with liver metastases of CRC.
The optimal timing of liver resection, resection of the primary tumor and neoadjuvant chemotherapy has not been fully established, yet, neither for initially resectable synchronous liver metastases, nor for those initially unresectable which could be converted to resectability. Advocates of simultaneous resect....[more]

Read article Breast cancer is one of the leading causes of mortality worldwide. Genomic studies have provided key insights into how breast cancer develop, evolve, metastasize, recurrence and respond to treatment. The advance of next-generation sequencing (NGS) and bioinformatics has led to an unprecedented view of the breast cancer genome and its evolution, and made the dynamic monitoring of recurrence and selective evolution of breast cancer during therapy a reality.
Here we illustrate a proposed preclinical strategy of personalized and dynamic therapy for breast cancer based on the technolo....[more]

Read article Adult patients who present with papilloedema and symptoms of raised intracranial pressure need urgent multidisciplinary assessment including neuroimaging, to exclude life-threatening causes. Where there is no apparent underlying cause for the raised intracranial pressure, patients are considered to have idiopathic intracranial hypertension (IIH).

Objectives: This review encompasses the newly revised diagnostic criteria for PTCS in adults and children and the role of obesity in the epidemiology, etiology, and management of IIH.Furthermore, this paper tries to offer a pr....[more]

Read article Background: the increasing of the numerus clausus becomes difficult to perform surgical clerkship (6th year) in just one hospital. So it became necessary to have the collaboration of Affiliated Hospitals (AH). This research corresponds to the comparative analysis of that clerkship in those institutions.

Methods: A voluntary and anonymous assessment was conducted by 913 (49.3%) of the 1851 students who attended surgical clerkship in the school years 2007-2008 to 2013-2014 in Oporto Medical School. Surveys were collected corresponding to the student's assessment ....[more]

Read article Bone regeneration techniques cannot be done without barrier membranes, even if horizontal or vertical ridge augmentation and socket ridge preservation is taken into consideration. This study presents a comparison between outcomes of bone regeneration, after producing standardized bone defects followed by covering them with membranes, on an animal experimental model. The study was conducted on 18 New Zeeland rabbits, by creating 2 defects in the left tibial bone of each rabbit: one standardized defect with a diameter of 4 mm, and the second by creating 5 monocortical holes with a smal....[more]

Read article Background Aim: This pilot study was designed to investigate the feasibility to close protective loop stomas during the same hospital admission based on data on morbidity and mortality, health-related quality of life and healthcare-related costs shortly after the initial operation as well as to find out the causes that delay the closure and to compare the same admission closure with the delayed closure.

Methodology: We created a temporary small bowel stoma due to various pathology and these patients were divided into two groups i.e one with early closure group ....[more]

Read article Introduction: Due to the relatively low prevalence of hepatitis delta in Europe, Romania is one of the main countries in the region that can provide data on long-term prognosis of patients with this condition.

Methods: We performed a retrospective study to assess liver disease progression and to compare non-invasive methods for assessing liver fibrosis in patients with chronic hepatitis B and delta under current active surveillance at the National Institute for Infectious Diseases Prof. Dr. Matei Balasa, Bucharest, Romania.

Results: The study gro....[more]