Surgery, Gastroenterology and Oncology

Read article The prognostic factors of patients with colorectal liver metastases (CLM) have been traditionally searched among the factors related to the primary colorectal tumor or to CLM.
While many different scoring systems have been developed based on those traditional clinic-pathological factors, there has been the introduction of genetic biomarkers that added a theragnostic perspective.
More recently, other important factors, such as those related to the host immune system, have been proposed as new determinants of prognosis of CLM patients. We herein review the current prognosti....[more]

Read article Background: Several clinical risk factors for patients undergoing liver resection for colorectal liver metastases were suggested. The purpose of the study was to evaluate the prognostic factors for survival after resection of liver metastases from colorectal cancer in a high volume center for both hepatobiliary and colorectal surgery.

Methods: We completed a retrospective analysis on 655 consecutive patients with liver resection for colorectal cancer metastasis operated in our centre between April 1996 and March 2016. Preoperative, intraoperative, pathologic, a....[more]

Read article Background: Colorectal cancer is one of the most common diagnosed malignancies in the world. Successful treatment is related not only to the resection of the main tumor mass but also to the destruction of colorectal cancer cells which are highly resistant to chemoradiotherapy, with unlimited self-renewal and tumor-initiating capacities.
CD44 is an important adhesion molecule and one of the proposed stem cell markers in colorectal cancer known to be involved in cell growth, differentiation and survival. Aim: We conducted a prospective study with the aim of evaluating the ....[more]

Read article Background: About one third of patients racically resected for colorectal cancer develop during follow-up recurrence. Materials and methods: There were 1951 patients operated for colorectal cancer in Surgical Department, Thomayer Hospital Prague, from 1997 to 2015.
Radical R0 operation underwent 68% of these patients. Postoperative complications occurred in 457 (34.6%) patients. Impact of postoperative complications on disease free interval was studied in a prospective study.

Results: We identified minor complications in 90 patients (6.8%), moderate complic....[more]

Read article Background: p53 mutation is the most common genetic alteration in cancers and influences clinical progression. Ki-67 protein is a cellular marker for proliferation in cancer or premalignant lesion.
The aim of this study is to investigate whether p53 and Ki-67 measurements in gastric tumors would be helpful in determining treatment strategy.
Methods: Immunohistochemical staining using monoclonal antibodies to p53 and Ki-67 was performed on specimens from 29 gastric adenomas (GA) by endoscopic submucosal dissection (ESD) and 240 gastric cancers (GC) by ESD or g....[more]

Read article Hepatocellular carcinoma is the fifth most common cancer worldwide and one of the leading causes of cancer-related mortality. The majority of patients with hepatocellular carcinoma have underlying liver cirrhosis as a result of hepatitis B or hepatitis C virus, and alcoholic hepatitis.
Its management in the presence of liver cirrhosis is a complex condition. Selecting the appropriate treatment modality is dependent not only on tumor stage, but also on the severity of the underlying liver disease. Liver resection and transplantation remain the main course of treatment of HCC. more]

Read article Purpose: Pancreaticoduodenectomy (PD) is considered a complex surgical procedure that is associated with a high morbidity. There has been no report on the optimal duration of prophylactic antibiotics administration to date. Mortality and morbidity, including surgical site infection (SSI) after PD, were compared retrospectively taking into account the period of prophylactic antibiotics administration.

Methods: This study involved 158 patients who underwent PD between April 2006 and December 2010. Until March 2008 our hospital administered prophylactic antibiotic....[more]

Read article Background: The optimal timing of surgery is still controversial when preoperative gallbladder drainage (PGD) has been performed for AC.

Method: Between 2010 and 2015, 77 AC patients, who consecutively underwent surgery, were divided into two groups. One was the group on which PGD were performed (n=39), and the other was patients that underwent emergency operations (EO) without PGD (n=38). The PGD group was further divided into two groups: one with the period from drainage to surgery of 14 days (PGD-E n=17) and in the other the period was 14 days (PGD-D n=22). ....[more]

Read article Hydatid cyst is a parasitic disease caused by Echinococcus granulosus, and it is endemic in some regions of the world, including Romania. Liver and lungs are the main locations for primary hydatid cyst, while the pancreatic location of the disease is exceptional.
It is presented the case of a 34-years-old male diagnosed at computed tomography with a large cystic lesion of the pancreatic body and tail considered as a cystic pancreatic neoplasm.
The patient underwent a distal spleno-pancreatectomy, and after transection of the operative specimen, it was revealed a pancreati....[more]