Surgery, Gastroenterology and Oncology
Vol. 23, No. 2, Apr 2018
Treatment Strategies in Hepatocellular Carcinoma
Charles W. Kimbrough and Timothy M. Pawlik
Leading Article, Apr 2018
Article DOI: 10.21614/sgo-23-2-95
Read article Hepatocellular carcinoma (HCC) is the most common primary liver malignancy worldwide, and a leading cause of global cancer-related mortality. However, a multitude of risk factors results in heterogeneous tumor biology that can demonstrate widely different clinical behaviors. Chronic inflammation represents the predominant etiology of HCC, and up to 80-90% of cases occur in the setting of cirrhosis. The underlying liver disease observed in most patients adds an additional level of clinical complexity not present in most other cancers. Careful consideration of the tumor biology, liver ....[more]
The Pathogenesis of Gastric Carcinoma
Elroy Patrick Weledji
REVIEW, Apr 2018
Article DOI: 10.21614/sgo-23-2-106
Read article Gastric cancer is one of the leading causes of cancer mortality in the world. Gastric adenocarcinomas account for more than 95% of gastric tumours, and these epithelial tumours result from the accumulation of multiple genetic defects which leads to uncontrolled growth. The most plausible pathway for gastric carcinoma indicates that the underlying mechanisms may be different for the diffuse and intestinal types of tumour.
The distinct subtypes - proximal, diffuse and distal gastric cancer that are different from a histological and epidemiological standpoint, can also distinguish....[more]
Red-flag Techniques for the Assessment of Pre-Neoplastic Gastric Lesions: Autofluorescence Imaging versus Virtual Chromoendoscopy
Maria Monalisa Filip, Sevastiţa Iordache, Elena Daniela Burtea, Mihaela Căliţa, Adrian Săftoiu
Article DOI: 10.21614/sgo-23-2-115
Read article Background Aim: The endoscopic diagnosis of preneoplastic lesions and early gastric cancer is based on subtle morphological changes, which are difficult to recognize during routine examinations. The study was performed in order to establish the role of autofluorescence imaging (AFI) and magnifying endoscopy with narrow band imaging (ME-NBI) for the diagnosis of premalignant gastric lesions.

Methods: The study included patients with dyspeptic symptoms and or known risk factors for gastric cancer. Imaging consisted of white light endoscopy (WLE), followed by AFI....[more]
The Combination of Serum Cystatin C, Urinary Kidney Injury Molecule-1 and MELD plus Score Predicts Early Acute Kidney Injury after L....
Marian-Irinel Tudoroiu, Georgiana Constantin, Liliana Pâslaru, Speranţa Iacob,Cristian Gheorghe, Irinel Popescu, Dana Tomescu, Liliana Simona Gheorghe
Article DOI: 10.21614/sgo-23-2-121
Read article Introduction: Acute kidney injury (AKI) following liver transplantation (LT) is a frequent complication and is associated with increased morbidity and mortality.

Aim: To investigate whether the levels of urinary KIM-1 and serum Cystatin C are able to predict early occurrence (within the first 48 hours) of the post-LT renal dysfunction. Methods: The study was conducted on 25 recipients transplanted in the Fundeni Clinical Institute between May 2016 and February 2017. Serum Cystatin C, urinary KIM-1 and serum creatinine were analysed before LT, as well as....[more]
Strategies and Techniques for the Treatment of Concomitant Gallbladder and Common Bile Duct Stones: An Economic Dilemma Only?
Antonio Zanghi, Andrea Cavallaro, Sergio Castorina, Maria Di Vita, Laura Fisichella, Francesco Cardi, Fabio Melandro, Alessia Giaquinta, Alessandro Cappellani
Article DOI: 10.21614/sgo-23-2-127
Read article Background: Single stage laparoendoscopic rendez-vous (LERV), single-stage laparoscopic common bile duct exploration - cholecystectomy (LCBDE), and two-stage endolaparoscopic (LC-ERCP) management of cholecystocholedocholithiasis can be performed with similar short and long-term outcomes. This multicentric study retrospectively examined the outcome and hospital costs of one-stage vs. sequential two-stage strategies of treatment.

Methods: From January 2013 to December 2016, all the patients affected by cholecystocholedocholithiasis and treated at 2 different med....[more]
What are the Risk Factors for Non-Alcoholic Fatty Liver Disease after Pancreatoduodenectomy?
Mitsugi Shimoda, Takayuki Shimizu, Yoshimi Iwasaki, Masato Kato, Keiichi Kubota
Article DOI: 10.21614/sgo-23-2-134
Read article Background: Although hepatic steatosis is often observed after pancreatoduodenectomy (PD), its preoperative clinical features remain unclear. This study focused on the risk factors for non-alcoholic fatty liver disease (NAFLD) after PD.

Methotology: Between April 2008 and June 2011, 100 patients underwent subtotal stomach-preserving PD (SSPPD) for pancreatic head or periampullary diseases. We divided the patients into two groups: a NAFLD group (NA group) and a non-NAFLD group (non-NA group). We compared risk factors such as BMI, blood parameters, blood cell co....[more]
A Study of Incidence and Significance of Intraoperative Peritoneal fluid Fungal Culture in Patients with Perforated Peptic Ulcers
Mahim Koshariya, Surabhi Garg, Anshul Siroliya, Abhishek Shitole, Rakesh Pandey, Amit Katlana, Arvind Rai
Article DOI: 10.21614/sgo-23-2-142
Read article Background: Although the incidence of peptic ulcer disease has reduced, the peptic ulcer perforation rates remain constant. Till recently the emphasis has been placed on the identification of microbial flora associated with peritonitis caused by perforated peptic ulcer.
The aim of this study was to determine the incidence and significance of intraoperative peritoneal fluid culture of fungus in patients with perforated peptic ulcers.

Materials and method: In this study, we included 53 patients with intraoperatively confirmed perforated gastroduodenal ulce....[more]
Liver Resection for Metastasis of Rectal Cancer Origin in a Polycystic Liver
Mircea Pavel, Alexandru Procop, Patricia Boeti-Sarbu, Radu Dumitru, Traian Dumitrascu
Images in Clinical Medicine, Apr 2018
Article DOI: 10.21614/sgo-23-2-147
Read article Liver metastases of colorectal origin are a common pathology, and the most frequent indication for liver resection. Associated chronic liver pathology may potentially increase the difficulty of a liver resection. Hereby, it is presented the case of a 67-year-old woman with a liver metastasis of rectal cancer origin with concomitant polycystic liver disease. An atypical liver resection was performed with intraoperative ultrasound guidance.
Liver tumors developed on a polycystic liver are rarely described. For these particular cases, the diagnosis is challenging, but liver resect....[more]

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Journal Abbreviation: Surg. Gastroenterol. Oncol.

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