Surgery, Gastroenterology and Oncology

Read article Identification of biomarkers that correlate with prognosis is crucial in hepatocellular carcinoma (HCC) because of the high recurrence rates seen after surgical treatments. Serum levels of fetoprotein (AFP) are widely used clinically, but the prognostic value of AFP remains unclear.
AFP levels are influenced not only by the presence of HCC but also by the severity of the underlying liver disease. Furthermore, AFP could be normal in up to 30% of HCC patients. Thus, additional biomarkers are needed. Insulin-like growth factors 1 (IGF-1) is a growth factor with dose-dependent prol....[more]

Read article Nonalcoholic fatty liver disease (NAFLD) represents the accumulation of lipids in the hepatocytes, lipids represented by triglycerides (most frequently), cholesterol, phospholipids, and sphingolipids.
NAFLD is rapidly becoming one of the most important causes of chronic liver disease, liver cirrhosis and liver transplantation in developed countries. It can present as simple steatosis, which is usually a benign condition, to steatohepatitis, which may lead do advanced fibrosis and cirrhosis. Although there are many risk factors for the development of fatty liver disease, a centr....[more]

Read article Objectives: To study the function of the gastric mucosa and acid secretion after bariatric surgery, GastroPanel (GP), serum biomarker test was performed in 29 laparoscopic sleeve gastrectomy (LSG) and 28 laparoscopic Roux-en-Y gastric bypass (LRYGB) patients before and after surgery.

Methods: Pepsinogen I (PGI), II (PGII), basal fasting gastrin-17 (G17b), stimulated gastrin-17 (G17s) and Helicobacter pylori antibody (HPAB) levels in serum were assayed preoperatively, postoperatively on days 1 and 3, and after 1, 3 and 12 months.

Results: The serum....[more]

Read article Background: Biliary strictures (BSs) often represent a diagnostic challenge when evaluated with conventional endoscopic techniques. Many recent studies have focused on the specificity, sensitivity and accuracy of digital single-operator cholangioscopy (DSOC) in cases of BSs. However, DSOC is not a standardized procedure and the institutional experience with DSOC when used in different settings can provide important information.

Methods: This is prospective study of consecutive patients undergoing DSOC from March 2016 until March 2018. The aims of the study wer....[more]

Read article Introduction: Prognosis of metastatic colorectal cancer (mCRC) patients nowadays is an important subject in the field of oncology. R0-resection of colon with primary tumor and liver metastasis remains the only treatment which significantly improves survival rate. However, recent experimental data shows that surgical trauma can indirectly stimulate tumor growth due to mitochondrial dysfunction and unregulated superoxide radical (O2-.) generation.

Aim: To study the clinical significance of 8-hydroxy-deoxyguanosine (8-OHdGu) marker, to assess the oncological effec....[more]

Read article Background: Liver abscess is a common condition in India and it has the 2nd highest incidence of liver abscess in the world. Pyogenic abscess accounts for three quarters of hepatic abscess in developed countries while amoebic liver abscess causes two third of liver abscess in developing countries. Amoebiasis is presently the third most common cause of death from parasitic disease. The world health organisation reported that Entamoeba histolytica causes approximately 50 million cases and 1,00,000 deaths annually. Liver abscess continues to be a disease with considerable mortali....[more]

Read article A restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) has been considered a gold standard surgical procedure for patients with ulcerative colitis (UC). Even if patients with UC underwent high quality IPAA after proctocolectomy, pouch related complications occurred in over 50% of them more than five years after surgery.
The most common pouch related complication is pouchitis including frequent bowel movements, urgency, cramping and bloody stools. We experienced unusual postoperative pouch related complication, pouch inertia, in two female patients over ten years....[more]

Read article Introduction: Von Hippel Lindau disease (VHLD) is a rare autosomal-dominant disorder. Multiorgan cysts and low histological grade tumors with various localizations are characteristic for VHLD. Imaging studies are important for the evaluation of VHLD patients.

Case report: We report the case of a 53 years old woman who was admitted for weight loss, chronic abdominal pain and mild jaundice. The patient was known with a cerebral tumor previously removed. Family history was suggestive for VHLD. US showed voluminous cystic lesions developed on the kidneys and in the....[more]

Read article Hydatid cyst of the liver is part of hepatic surgery in which the check of bile leakage is mandatory to avoid severe complications.
The bile leakage test using air bubbles, leaves the surgical field with natural colours and especially in case of identification of multiple holes, results in safer application compared to methylene bleu.