Surgery, Gastroenterology and Oncology
Vol. 25, Nr. 4, Sept 2020
Enteral Versus Parenteral Nutrition for Postoperative Pancreatic Fistula: A Systematic Review and Meta-analysis
Sandra Lee, Tyler McKechnie, Yung Lee, Kasia Tywonek, Aristithes Doumouras, Leyo Ruo, Pablo E. Serrano
Systematic Review, Sept 2020
Article DOI: 10.21614/sgo-25-4-170
Read article Background: Postoperative pancreatic fistula (POPF) remains a significant source of morbidity following pancreatic surgery. The most effective feeding route for the conservative management of POPF is currently unknown. We aimed to compare the efficacy of enteral to parenteral nutrition in the rate of POPF closure.

Methods: Medline, EMBASE, CENTRAL, and Web of Science were searched for randomized controlled trials (RCTs) comparing enteral to parenteral nutrition in the conservative management of POPF. Risk of bias was assessed using the Cochrane Risk of Bias Tool....[more]
Is Splenectomy Always Effective on Liver Regeneration of Extended Left Lobe Graft After Living Donor Liver Transplantation?
Yasuhiro Maruya, Susumu Eguchi, Masaaki Hidaka, Akihiko Soyama, Takanobu Hara, Florian Pecquenard, Kantoku Nagakawa, Tomoko Yoshimoto-Haramura, Hajime Matsushima, Takayuki Tanaka, Tomohiko Adachi, Shinichiro Ito, Kengo Kanetaka
Systematic Review, Sept 2020
Article DOI: 10.21614/sgo-25-4-183
Read article Background Aims: The effect of splenectomy on the liver regeneration of a partial graft after living donor liver transplantation (LDLT) is controversial. In recent years, some studies have shown that platelets have strong effects on promoting liver regeneration, but not with a smallfor- size liver graft. This study aimed to validate the effects of splenectomy on liver regeneration rate after LDLT with extended left lobe graft with the middle hepatic vein.

Methodology: Of 312 LDLT to date, 32 adult patients at Nagasaki University Hospital (Nagasaki, Japan) transp....[more]
Is PARP-1 Inhibitor (Nutlin3a) Effective on Hepatic Ischemia-Reperfusion Injury?
Daisuke Kawahara, Kosho Yamanouchi, Naoyuki Okita, Yoshikazu Higami, Yusuke Inoue, Shinichiro Ito, Masaaki Hidaka, Kengo Kanetaka, Fumihiko Fujita, Susumu Eguchi
Article DOI: 10.21614/sgo-25-4-189
Read article Background Aims: Nutlin3a is known to have effects of stabilization of p53 and degradation of Poly(ADP-ribose) polymerase 1 (PARP1) in cell-specific manner. It was demonstrated that nutrlin3a decrease tissue damage caused by ischemia reperfusion (I R) in transplant settings such as lung. We aimed to evaluate if the reagent would still alleviate hepatic I R injury.

Methodology: First, to evaluate an efficacy of nutlin3a in normal liver, we administered it to male C57Bl 6 mice intraperitoneally at doses of 0 (vehicle only), 5, and 20 mg kg of body-weight. The an....[more]
Long-Term Results of Surgical Repair of Bile Duct Injuries Following Laparoscopic Cholecystectomy
Ghofrane Talbi, Wael Ferjaoui, Mohamed Hajri, Houssem eddine Smati, Sahir Omrani, Dhouha Bacha, Rached Bayar, Lasaad Gharbi, Mohamed tahar Khafallah
Article DOI: 10.21614/sgo-25-4-194
Read article Background: The iatrogenic injury of the bile ducts is a serious accident of laparoscopic cholecystectomy. Its management is multidisciplinary. The aim of our work was to elucidate the factors influencing the long-term results after biliary repair.

Methods: A retrospective, analytical and descriptive study was carried out on a series of 44 cases of biliary injuries repaired over a period of 14 years.

Results: The injury was discovered intraoperatively in 18 cases, in early postoperative period in 20 cases and in late postoperative period in 6 case....[more]
Result of Applying Laparoscopic Total Gastrectomy with D2 Lymph Node Dissection with Left-Site Surgeon and Final Resection and Closu....
Van-Huong Nguyen, Van-Chien Dinh, Van-Quyet Ha, Van-Duyet Pham, Van-Thuong Pham,Quoc-Ai Dang
Article DOI: 10.21614/sgo-25-4-199
Read article Objective: To evaluate the outcomes, safety and effectiveness of laparoscopic total gastrectomy with D2 lymph node dissection with left-site surgeon and resection - closure of the duodenal stump in final phase after making esophageal anastomosis in gastric cancer treatment.

Method: Prospective, descriptive study on patients undergoing laparoscopic total gastrectomy and D2 lymphadenectomy with left-site surgeon and resection - closure of the duodenal stump in final phase after making esophageal anastomosis in gastric cancer treatment from 06 2016 รข?" 03 2020. <....[more]
A Case of Hereditary Gastrointestinal Stromal Tumor (KIT Mutation p.Asp820Tyr) in a Portuguese Family and a Good Response to Imatini....
Vítor Devezas, Hugo Santos-Sousa, Silvestre Carneiro, Elisabete Barbosa, José Barbosa
Images in Clinical Medicine, Sept 2020
Article DOI: 10.21614/sgo-25-4-206
Read article Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the human gastrointestinal tract. They are derived from transformed neoplastic precursors of the interstitial cells of Cajal.
They account for 0.1% to 3% of all gastrointestinal cancers. Up to 20% of cancers of the small bowel are GISTs. Less than 5% of cases are associated with hereditary predisposition, like Neurofibromatosis type I, Carney syndrome, and Familial GIST syndrome. The latter, is a rare autosomal dominant genetic disorder originated by germline gain-of-function mutations of KIT or PDGF....[more]
Mutational Analysis in Gastrointestinal Stromal Tumors - A Series of Three Cases
Alexandra Roşulescu, Adina Croitoru, Andreea Iorgescu, Gabriel Becheanu, Alexandru Procop,Victor Tomulescu, Vlad Croitoru, Vlad Herlea
Research, Sept 2020
Article DOI: 10.21614/sgo-25-4-213
Read article Background: Most of the Gastrointestinal Stromal Tumors (GISTs) are determined by mutations in C-KIT or PDGFRA genes. Mutation type influences the clinical evolution and treatment response. Case reports: This study aims to present particular cases of GIST referred for molecular testing, diagnosed and treated in our institution.

Results: We present three cases in which genetic testing was performed. The first patient was diagnosed in a short-time interval with two GISTs, a gastric and a jejunal one, both with low risk of recurrence. To establish the relationship ....[more]

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Journal Abbreviation: Surg. Gastroenterol. Oncol.

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