Surgery, Gastroenterology and Oncology

Read article Background: Postoperative pancreatic fistula (POPF) remains a significant source of morbidity following pancreatic surgery. The most effective feeding route for the conservative management of POPF is currently unknown. We aimed to compare the efficacy of enteral to parenteral nutrition in the rate of POPF closure.

Methods: Medline, EMBASE, CENTRAL, and Web of Science were searched for randomized controlled trials (RCTs) comparing enteral to parenteral nutrition in the conservative management of POPF. Risk of bias was assessed using the Cochrane Risk of Bias Tool....[more]

Read article Background Aims: The effect of splenectomy on the liver regeneration of a partial graft after living donor liver transplantation (LDLT) is controversial. In recent years, some studies have shown that platelets have strong effects on promoting liver regeneration, but not with a smallfor- size liver graft. This study aimed to validate the effects of splenectomy on liver regeneration rate after LDLT with extended left lobe graft with the middle hepatic vein.

Methodology: Of 312 LDLT to date, 32 adult patients at Nagasaki University Hospital (Nagasaki, Japan) transp....[more]

Read article Background Aims: Nutlin3a is known to have effects of stabilization of p53 and degradation of Poly(ADP-ribose) polymerase 1 (PARP1) in cell-specific manner. It was demonstrated that nutrlin3a decrease tissue damage caused by ischemia reperfusion (I R) in transplant settings such as lung. We aimed to evaluate if the reagent would still alleviate hepatic I R injury.

Methodology: First, to evaluate an efficacy of nutlin3a in normal liver, we administered it to male C57Bl 6 mice intraperitoneally at doses of 0 (vehicle only), 5, and 20 mg kg of body-weight. The an....[more]

Read article Background: The iatrogenic injury of the bile ducts is a serious accident of laparoscopic cholecystectomy. Its management is multidisciplinary. The aim of our work was to elucidate the factors influencing the long-term results after biliary repair.

Methods: A retrospective, analytical and descriptive study was carried out on a series of 44 cases of biliary injuries repaired over a period of 14 years.

Results: The injury was discovered intraoperatively in 18 cases, in early postoperative period in 20 cases and in late postoperative period in 6 case....[more]

Read article Objective: To evaluate the outcomes, safety and effectiveness of laparoscopic total gastrectomy with D2 lymph node dissection with left-site surgeon and resection - closure of the duodenal stump in final phase after making esophageal anastomosis in gastric cancer treatment.

Method: Prospective, descriptive study on patients undergoing laparoscopic total gastrectomy and D2 lymphadenectomy with left-site surgeon and resection - closure of the duodenal stump in final phase after making esophageal anastomosis in gastric cancer treatment from 06 2016 â?" 03 2020. <....[more]

Read article Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the human gastrointestinal tract. They are derived from transformed neoplastic precursors of the interstitial cells of Cajal.
They account for 0.1% to 3% of all gastrointestinal cancers. Up to 20% of cancers of the small bowel are GISTs. Less than 5% of cases are associated with hereditary predisposition, like Neurofibromatosis type I, Carney syndrome, and Familial GIST syndrome. The latter, is a rare autosomal dominant genetic disorder originated by germline gain-of-function mutations of KIT or PDGF....[more]

Read article Background: Most of the Gastrointestinal Stromal Tumors (GISTs) are determined by mutations in C-KIT or PDGFRA genes. Mutation type influences the clinical evolution and treatment response. Case reports: This study aims to present particular cases of GIST referred for molecular testing, diagnosed and treated in our institution.

Results: We present three cases in which genetic testing was performed. The first patient was diagnosed in a short-time interval with two GISTs, a gastric and a jejunal one, both with low risk of recurrence. To establish the relationship ....[more]