Surgery, Gastroenterology and Oncology

Read article We review herein the available data regarding the potential relationship between antidepressants and breast cancer. According to some studies, the biological rationale leading correlation among antidepressants and mammary carcinogenesis is represented by the increase in prolactin levels and by the promotion of cell proliferation.
However, these studies seem to be spoiled by an unsatisfactory statistical design and by the lack of a good control for confounding elements. Thus, experimental and clinical data remain controversial, even though recent studies tend to exclude a causat....[more]

Read article Objective: Identification of clinical and biological characteristics of breast cancer in women with mammary Paget's disease (MPD).

Methods: We performed a retrospective analysis for 36 women with a primary diagnosis of mammary Paget's disease, patients were treated in Sant Orsola-Malpighi Breast Unit in Italy, between 2000 and 2016. Patients demographics, clinical data, radiologic and pathologic reports were extracted from electronic health records.

Result: 36 cases of patients with a diagnosis of MPD were involved. The mean age was 64.28 years....[more]

Read article Background: Recent work has identified time taken to remove a donor liver during organ retrieval (the extraction time) as a previously unrecognized variable affecting transplant outcome. We evaluated the effect of extraction time on early graft function in our own practice in a busy liver centre. Patients and

Methods: 218 recipients of liver grafts transplanted at our centre (Addenbrooke's, Cambridge) between October 2014 and October 2017 were evaluated. Early graft function was assessed by model for early allograft function (MEAF) score in both univariate and m....[more]

Read article Background: Enhanced recovery after surgery (ERAS) protocol has been shown to reduce recovery period and postoperative complications. This prospective study aimed to evaluate the short-term outcomes of ERAS in patients who underwent upper gastrointestinal (UGI) surgery.

Methods: Patients who underwent surgery for benign or malignant diseases of the esophagus, esophagogastric junction, or stomach during October 2018-December 2019 were included. Outcomes compared between ERAS and conventional care (CC) included length of hospital stay (LOS), postoperative complica....[more]

Read article Introduction: Gastrointestinal stromal tumor (GIST) is the commonest mesenchymal tumour of the gut. However, the epidemiology of the disease in Egypt is not adequately studied.

Methods: A retrospective cohort study was conducted on patients treated for GIST from June 2008 to April 2018 in a tertiary center. Sixty-two cases were eligible for the study.

Results: The stomach was the commonest tumor site. The incidence of tumor residue was higher in extra-gastric (intestinal) GISTs. Laparoscopy was more frequently used in gastric GIST surgery. Overall....[more]

Read article Background: The stage-IV Colorectal adenocarcinoma patients who cannot be treated with any conventional cancer treatment (surgery, chemotherapy, or radiotherapy) belong to the best supportive care group. Very low carbohydrate diet reduces the glucose supply to the cancer cells through the specific metabolic pathway called the Warburg effect.
The cancer cell may "starve" and limit the growth that can be measured by the reduction of the systemic inflammation reaction using modified Glasgow Prognostic Score (mGPS). This study aimed to prove that a very low carbohydrate diet....[more]

Read article Introduction: Melanoma is a highly aggressive tumor that carries a poor prognosis. There are several reported cases of secondary splenic melanoma but there is only one reported case of primary splenic melanoma yet. Case presentation: A 35-year-old male, complaining from left lumbar pain.
Abdominal ultrasound revealed a mass at the lower pole of the spleen measuring 10x7x7 cm. Computed Tomography (CT) described a necrotic focal lesion involving its lower pole measuring 11 x 9 cm. US-guided fine needle aspiration (FNA) was suggestive of lymphoma, but tissue biopsy was reco....[more]

Read article Introduction: Abdominal hernias are more frequent in obese patients, associating more complications and worse therapeutic outcomes. These patients require a multidisciplinary treatment approach, including bariatric and hernia teams, and carried out in a specialized center.

Objective: To present the case of a 42yo obese patient with giant ventral hernia, and to discuss our therapeutic approach. This is a video presentation of a case report and literature review about the state of the art for hernia repair in obese patients.

Case report: 42 year-....[more]