Surgery, Gastroenterology and Oncology

Background Aims: The aim of this study is to evaluate long-term outcome of 3-week method (3-week administration followed by 1-week rest) for colorectal cancer as adjuvant chemotherapy with an oral anticancer drug, S-1.

Methods: Between 2008 and 2012, 142 patients with stage III colorectal cancer who underwent curative resection in our hospital and received oral adjuvant chemotherapy with S-1 for six months were enrolled in this study.
They were divided into two groups, 3-week method or 4-week method (4-week administration followed 2-week rest).

Results: The six-month completion rate in the 3-week method group was 100% (49 49) which was significantly better than that in the 4-week method group, 85% (79 93) (p=0.002). In total patients, five-year relapse-free survival rates in the 3-week method group was 89.6% which was significantly better than that in the 4-week method group, 74.2% (p=0.027).
There were no grade 3 or 4 adverse reactions in both laboratory and clinical findings in the 3-week method group.

Conclusions: The 3-week method of S-1 administration had good feasibility, high accumulated dose in six months and good relapse-free survival rates. The 3-week method with S-1 seems to be a standard adjuvant chemotherapy schedule for colorectal cancer.

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