Surgery, Gastroenterology and Oncology

Ovarian cancer is the most common cause of lethality among women with gynecological cancers. In Europe, it ranks fifth in frequency in women after malignancies of the mammary gland, colon, lung and uterine body. Generally, it is diagnosed at an advanced stage (III-IV) due to the non-specificity of symptoms in the early stage and the lack of effective screening methods. The majority of patients with advanced epithelial ovarian cancer are indicated either for neoadjuvant chemotherapy followed by optimal cytoreduction or optimal cyto-reduction followed by adjuvant chemotherapy. This ....[more]

Background: Lymph node metastases are very common in papillary thyroid carcinoma affecting the survival of patients. The appropriate management of cervical lymph nodes is very important. Therefore, this study evaluated the utility of sentinel lymph node biopsy (SLNB) using methylene blue in the central neck compartment. Objective: The aim of this study is to investigate the possibility of using the SLNB to predict micro metastasis in papillary carcinoma of thyroid to avoid the unnecessary central lymph node dissection.

Patients and Methods: This pro....[more]

Background: the prevalence of peptic ulcer (PU) is declining in Western because of widespread use of Helicobacter pylori (H. pylori) eradication drugs, however, it still high in developing regions. The study aimed to explore certain aspects of cases with PU and to identify the predictors of PU related to risk factors.

Material and Methods: the study was conducted at the endoscopic unit at Al-Sadr Teaching Hospital. A cross-sectional study involving 152 cases who underwent endoscopic examination by specialist doctors. All patients were inte....[more]

Background: acute kidney injury (AKI) is a prevalent complication that occurs following liver transplantation (LT). Aim: to evaluate the value of urinary neutrophil gelatinase-associated lipocalin (UNGAL) in detecting AKI following LT.

Material and Methods: the present study adopted a randomized, prospective, double-

blinded design. The trial was carried out on 38 patients who underwent evaluation for AKI

following LT at Menoufia University’s National Liver Institute. The study took place between January 2023 and June....[more]

Introduction: RAS mutations, particularly KRAS and NRAS mutations, are frequent drivers of metastatic colorectal cancer (mCRC) and confer resistance to anti-EGFR targeted therapy. This study investigated the impact of RAS molecular testing on treatment patterns and survival outcomes in Moroccan mCRC patients.

Material and Methods: A retrospective study was conducted among patients diagnosed mCRC and treated at Ibn Rochd University Hospital, Casablanca, Morocco, between 2019 and 2023. All patients received first-line chemotherapy followed b....[more]

Purpose: Primary retroperitoneal tumors (PRT) are various heterogeneous types of

neoplasms that have a frequency of less than 1%. The main factors associated with survival are time with the disease, treatment received, and recurrence. This study analyzed the clinical and pathological factors that influence the survival outcomes in patients with PRT.

Material and Methods: A retrospective cohort study and a survival analysis were conducted using the available data in the electronic clinical records of patients with a diagnosis of PRT....[more]

Cutaneous squamous cell carcinoma is the second most common skin cancer. Cemiplimab, an antiPD-1 monoclonal antibody, is the first immunotherapy approved for patients with locally advanced cSCC. Phase I and II studies showing high antitumor activity and good tolerability of cemiplimab. However, very little data is available on cemiplimab in real life and in frail, elderly and immunocompromised patients. We report the case of an elderly patient (84 years old) affected by metastatic cSCC. The patient performed 16 cycles of treatment with cemiplimab with complete pathological respons....[more]

Background: Primary hepatic neuroendocrine tumors (PHNETs) are very rare tumors. The diagnosis and management of PHNET remains an unusual and challenging issue.

Case Presentation: A 22-year-old woman, presented with recurrent dull aching right hypochondrial pain. She underwent detailed abdominal radiological evaluation revealing a well-defined mass lesion in the right hemi-liver measuring about 12 x 8 cm with vague

radiologic features. Upper and lower gastro-intestinal endoscopes were free. Upon exploration, there was a large mass ....[more]