Surgery, Gastroenterology and Oncology
Vol. 22, Nr. 4, December 2017
A Pilot Multicenter Study Evaluating the Expression of p53 and ki-67 in Gastric Tumors and Their Utility for Guiding Treatment Strategy
Il Hyun Baek, Kyoung Oh Kim, Jeong Won Kim, Kyeong Won Min
ORIGINAL PAPER, December 2017
Article DOI: 10.21614/sgo-22-4-318
Background: p53 mutation is the most common genetic alteration in cancers and influences clinical progression. Ki-67 protein is a cellular marker for proliferation in cancer or premalignant lesion.
The aim of this study is to investigate whether p53 and Ki-67 measurements in gastric tumors would be helpful in determining treatment strategy.
Methods: Immunohistochemical staining using monoclonal antibodies to p53 and Ki-67 was performed on specimens from 29 gastric adenomas (GA) by endoscopic submucosal dissection (ESD) and 240 gastric cancers (GC) by ESD or gastrectomy. Tumor cells with nuclear p53 and Ki-67 protein expression were arbitrarily graded into four groups: < 10 % = negative, 10-30 % = 1+, 30-60 % = 2+, and > 60 % = 3+.

Results: The mean tumor sizes in the GA and GC groups were 17.3 Â+- 11.4 mm and 32.0 +- 20.9 mm respectively (P < 0.001). p53 positivity was not different between the GA and GC groups (P = 0.149), but Ki-67 positivity was significantly different between the 2 groups (P = 0.001).
In addition, Ki-67 positivity tended to be increased as the pathologic progression changed from adenoma to cancer.

Conclusions: Ki-67 positivity grade seems to be correlated with malignancy potential. Even if endoscopic biopsy showed low grade dysplasia, in lesions with high Ki-67 positivity, it is better to consider active ESD rather than just long-term follow up.

Full Text Sources: Download pdf
Abstract:   Abstract EN
Views: 673

Video Abstracts

Open Access Fee

Members of the IASGO will not pay open access fee. Non-members of IASGO will pay publishing fee of €150. Publishing fee, which will cover the DOI, plagiarism check, the editing work.

Journal Subscriptions

Current Issue

June 2020


Instructions for authors
Online submission
Print ISSN: 2559 - 723X

ISSN-L: 2559 - 723X

ISSN online: 2601 - 1700

Surgery, Gastroenterology and Oncology is indexed in Scopus, CrossRef (DOI: 10.21614/sgo)

Meetings and Courses in 2020
Meetings and Courses in 2019
Verona expert meeting 2019
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.