Surgery, Gastroenterology and Oncology
Vol. 25, Nr. 4, Sept 2020
Is Splenectomy Always Effective on Liver Regeneration of Extended Left Lobe Graft After Living Donor Liver Transplantation?
Yasuhiro Maruya, Susumu Eguchi, Masaaki Hidaka, Akihiko Soyama, Takanobu Hara, Florian Pecquenard, Kantoku Nagakawa, Tomoko Yoshimoto-Haramura, Hajime Matsushima, Takayuki Tanaka, Tomohiko Adachi, Shinichiro Ito, Kengo Kanetaka
Systematic Review, Sept 2020
Article DOI: 10.21614/sgo-25-4-183
Background Aims: The effect of splenectomy on the liver regeneration of a partial graft after living donor liver transplantation (LDLT) is controversial. In recent years, some studies have shown that platelets have strong effects on promoting liver regeneration, but not with a smallfor- size liver graft. This study aimed to validate the effects of splenectomy on liver regeneration rate after LDLT with extended left lobe graft with the middle hepatic vein.

Methodology: Of 312 LDLT to date, 32 adult patients at Nagasaki University Hospital (Nagasaki, Japan) transplanted with an extended left lobe graft with middle hepatic vein between April 2013 and April 2019 were retrospectively assessed. In our department, the preoperative platelet count indicated for splenectomy is <= 50,000 L. Overall, 13 and 19 patients were included in the splenectomy and without splenectomy groups, respectively. We examined the relations hip between splenectomy and liver volume increase, and postoperative platelet count on the 1st, 3rd, 5th, and 7th postoperative day. The liver volume 1 month (1MVol) after LDLT was estimated using a 3D image analysis system.

Results: ROC curve analysis showed the spleen volume threshold for significant volume increase (1MVol graft weight >= 2) was 440ml. With regard to 1MVol, no significant difference was observed between the splenectomy and without splenectomy groups. However, in the splenectomy group, recipients with a large spleen (more than 440 ml) led to higher liver volume increase than in those with a small spleen. Platelet count significantly increased from postoperative day 14 in the splenectomy group regardless of the size of the spleen.

Conclusions: Simultaneous splenectomy does not always have an effect on liver regeneration in extended left lobe graft LDLT. However, for LDLT recipients with large spleen volume, graft volume increase was affected, probably through vigorous portal venous blood flow but not plateletderived factors.

Full Text Sources: Download pdf
Abstract:   Abstract EN
Views: 155



Video Abstracts


Open Access Fee

Members of the IASGO will not pay open access fee. Non-members of IASGO will pay publishing fee of €150. Publishing fee, which will cover the DOI, plagiarism check, the editing work.


Journal Subscriptions

Current Issue

Sept 2020

Supplements

Instructions for authors
Online submission
Contact
Print ISSN: 2559 - 723X

ISSN-L: 2559 - 723X

ISSN online: 2601 - 1700

Surgery, Gastroenterology and Oncology is indexed in Scopus, CrossRef (DOI: 10.21614/sgo)



Meetings and Courses in 2020
Meetings and Courses in 2019
Verona expert meeting 2019
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.