Surgery, Gastroenterology and Oncology
Vol. 25, Nr. 3, June 2020
Portal Pressure Impact on Clinical Outcome after Major Hepatectomy: A Systematic Review and Meta-Analysis
Jorge Humberto Gomes Carrapita, Ana Margarida Abrantes, Bernardo Sousa-Pinto, Jorge Nunes Santos, Maria Filomena Botelho, José Guilherme Tralhão, Jorge Maciel Barbosa
REVIEW, June 2020
Article DOI: 10.21614/sgo-25-3-113
Aim of the study: To systematically review the evidence regarding the association between portal venous pressure (PVP) after hepatectomy and posthepatectomy liver failure (PLHF) or other postsurgical outcomes.

Materials and methods: We searched PubMed, Scopus and Web of Science for studies assessing post-hepatectomy PVP (or its variation) and reporting its association with PHLF or other postsurgical outcomes. We performed a random-effects meta-analysis for the association between development of PHLF and post-hepatectomy PVP and its variation.
Heterogeneity was assessed using Q-Cochran test and I2 statistic. Quality assessment was performed considering ROBINS-1 Cochrane tool.

Results: Four studies, assessing 439 patients, met the eligibility criteria and were included in this systematic review. The meta-analyses, including 3 studies, demonstrated that patients developing PHLF did not have a significantly higher post-hepatectomy PVP when compared to the remainder (1.98; 95%CI=-1.44-5.39; p=0.256; I2=2%), but had a significantly higher PVP variation (increase) during hepatectomy (1.65; 95%CI=1.15-2.15; p<0.001; I2=0%). The quality of the studies allowed to consider the robustness of the conclusions as "median".

Conclusions: An increased PVP variation following hepatectomy associates with a higher risk of PHLF, but the same was not observed for the absolute value of post-hepatectomy PVP.

Full Text Sources: Download pdf
Abstract:   Abstract EN
Views: 442

Video Abstracts

Open Access Fee

Members of the IASGO will not pay open access fee. Non-members of IASGO will pay publishing fee of €150. Publishing fee, which will cover the DOI, plagiarism check, the editing work.

Journal Subscriptions

Current Issue

June 2020


Instructions for authors
Online submission
Print ISSN: 2559 - 723X

ISSN-L: 2559 - 723X

ISSN online: 2601 - 1700

Surgery, Gastroenterology and Oncology is indexed in Scopus, CrossRef (DOI: 10.21614/sgo)

Meetings and Courses in 2020
Meetings and Courses in 2019
Verona expert meeting 2019
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.