Surgery, Gastroenterology and Oncology
Vol. 19, Nr. 1-2, January October 2014
SURGERY. THE GENE PROFILE OF NON-SMALL CELL LUNG CANCER AND THE INVASION OF MEDIASTINAL GANGLIA
Mădălina Grigoroiu, Simona Dima, Anca Năstase, N. Bacalbaşa, Viktoria Laszlo, W. Klepetko, I. Popescu, J.F. Regnard
REVIEW, January October 2014
Article DOI: 10.21614/jtmr-19-2-14
Standard cytotoxic chemotherapy is effective for certain type of cancer; however, as far as many other types are concerned, the available treatments only offer a limited survival benefit. Lung cancer represents one of these types of cancer. The development of specific therapies is the greatest promise for the successful treatment of this disease; nevertheless, an oriented approach depends on the understanding of the tumor cells genome. The exon sequencing of a large number of lung cancer samples has provided an initial insight of the somatic mutation profile of these tumors. These studies have confirmed the high frequency of TP53 and KRAS mutations in lung cancer. They have discovered mutational inactivation in some suppressor genes of knowntumors that have not been previously associated with lung cancer. In addition, they haveidentified oncogene mutations of EGFR, which has led to the first targeted therapy in pulmonary adenocarcinoma. There are other oncogene candidates awaiting for functional validation. It is expected for the future sequencing of the entire exome and of the entire genome of lung cancer to reveal a more thorough view of somatic mutations that can be exploited for therapeutical purposes.

Full Text Sources: Download pdf
Abstract:   Abstract EN
Views: 818


Video Abstracts


Open Access Fee

Members of the IASGO will not pay open access fee. Non-members of IASGO will pay publishing fee of €150. Publishing fee, which will cover the DOI, plagiarism check, the editing work.


Journal Subscriptions

Current Issue

Mar 2021

Supplements

Instructions for authors
Online submission
Contact
Print ISSN: 2559 - 723X

ISSN-L: 2559 - 723X

ISSN online: 2601 - 1700

Surgery, Gastroenterology and Oncology is indexed in Scopus, CrossRef (DOI: 10.21614/sgo)



Meetings and Courses in 2021
Meetings and Courses in 2020
Meetings and Courses in 2019
Verona expert meeting 2019
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.