Pancreatic cancer represents one of the deadliest cancers with a high mortality rate, characterized by an aggressive local invasion and early metastases. This malignancy is poorly responsive to chemotherapy or chemo-radiotherapy. Several proangiogenic factors were associated with pancreatic carcinogenesis, highlighting the importance of using antiangiogenic agents as therapeutic strategy.
Further studies suggest the involvement of chronic inflammation in angiogenesis processes in pancreatic carcinogenesis and inflammatory cytokines should be considered as potential biomarkers, as well as therapeutic targets in pancreatic cancer patients.
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Cited by 1 articles
Journal: Journal of Immunology Research (2314-7156)
Article: A Morphological and Immunohistochemical Study of the Tumoral and Inflammatory Cells in Pancreatic Ductal Adenocarcinoma
Crossref DOI: 10.1155/2020/6148286